pentobarbital decreases amounts of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with strong CYP3A4 inducers; these medicine decrease exposure to vandetanib by around forty%.pentobarbital will reduce the level or effect of doxorubicin by impacting hepatic/intestinal enzyme CYP3A4 metabo… Read More